There's a lot more to it than which airline is the best. There's the cost, number of stops, total travel time, departure times, connecting time between flights, etc, etc. Try Expedia.com amd enter your information and see what comes up.
Joe, my experience over the years is the best way to go to Tucson from Detroit is Southwest. I do not think there are any airlines that fly nonstop to Tucson from Detroit. Southwest has some good connections in Albuquerque or Denver. They will be the most reasonable also. I would pay the extra $10 per person for priority boarding. Just my thoughts as I have done it many times.
The answer is very consistent.
Thankyou to all. I do appreciate your support.
This year I needed a new gun case , I acquired a new Americase from my friends
on here. The price was right & just what I needed.
Good Shooting to All. All the Best.