At one time, Hodgdon said they were able to be substituted safely. I have not seen that statement in the latest data. If you keep the pressures low, you are probably OK. I would ask the powder manufacturer about the particular load and go from there. At least drop the powder a half grain or so and stay away from the higher pressure loads. The Nobel Sport is also a larger diameter and will stretch the primer pockets out so a standard sized primer may not fit properly.