22-250 Remington is my favorite varmint caliber. Also one of the most popular. I own 2 rifles chambered in 22-250 Remington. The first is a Remington 700 Varmint and it shoots good with my reloads, and the second is a T/C Encore that I usually just shoot factory ammo out of. If you dont plan on reloading its no big deal because there is a wide selection of factory ammo to choose from.
I do and i love it.. my ruger m77in 22-250 is by far my favorite gun. Ive grouped 3 shots within a penny at 175yds consistantly. The 22-250 is the perfect balance between the low powered varmints like the 223 and the larger 6mm's and the 308.
i have had a win model 70 for several years but just started shooting it last summer. its a good round, fast and accurate. i still like my bushmaster varmiter in .223 better because i don't have to work the bolt.
Ruger No.-1B in 22-250, Remington 700 Classic in .220 Swift, Remington 700 Classic in 22-250(Getting a new Shilen #5 CM barrel to convert it to Varmint Special.) They are all really fantastic shooters. I use the Hornady 55 gr. V-Max
in the Swift, Hornady 60 gr. HP in the Ruger No-1B, and Sierra 52gr. HPBT in the 700 22-250. All bullets are moly treated. The Swift has a Leupold 12X on top. The Ruger No.1B has a Nikon 3x9 and the 700 22-250 has a Nikon 5.5x16.5.
These are the top end 22s. Little brothers are Hornets, standard and K,.218 Mashburn, .221 Fireball, .222 Rem and .223 Rem.
But if I'm really serious about p-dogs, I grab a .20/.223AI with 12x Leupold and send 'em to St. Peter. 32gr. V-Max or 36gr. Berger HP at about 4M really sends them.
I have a Browning 1885 in .22-250, topped with a Leupold 6.5-20x 40mm Ao with target knobs. I use it for coyotes, rockchucks and gray diggers (California ground squirrels).<br>
I don't use it for smaller critters in target rich environment, like sage rats. I have the same setup in a .223 for that.<br>
I remember watching my friend clean a groundhogs head off with a Remington .22-250 at about 285 yards - and I do mean cleaned it off. I was very impressed with both the rounds accuracy and power. If I ever buy a varmint gun that will be the caliber I choose.